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>   首页   >   产品   >   一抗   >   干细胞   >   PSCA Antibody   

PSCA Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O43653
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 11959 Da
Additional Information
Gene ID 8000
Other Names Prostate stem cell antigen, PSCA
Dilution WB~~1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name PSCA
Function May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor
Tissue Location Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts) Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.

REFERENCES

Reiter R.E.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:1735-1740(1998).
Bahrenberg G.,et al.Biochem. Biophys. Res. Commun. 275:783-788(2000).
Nusbaum C.,et al.Nature 439:331-335(2006).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).

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