SRSF3 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB, ICC, IHC-P |
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Primary Accession | P84103 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 19330 Da |
Gene ID | 6428 |
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Other Names | Serine/arginine-rich splicing factor 3, Pre-mRNA-splicing factor SRP20, Splicing factor, arginine/serine-rich 3, SRSF3, SFRS3, SRP20 |
Dilution | WB~~1:1000 ICC~~N/A IHC-P~~N/A |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | SRSF3 |
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Synonyms | SFRS3, SRP20 |
Function | Splicing factor, which binds the consensus motif 5'- C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA- binding protein that recognizes and binds N6-methyladenosine (m6A)- containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A- containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). |
Cellular Location | Nucleus. Nucleus speckle. Cytoplasm. Note=Recruited to nuclear speckles following interaction with YTHDC1. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. RNA-binding is semi-sequence specific.
REFERENCES
Zahler A.M.,et al.Genes Dev. 6:837-847(1992).
Liu W.L.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Barnard D.C.,et al.Mol. Cell. Biol. 20:3049-3057(2000).

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