癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TSC22 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, ICC, IHC-P |
|---|---|
| Primary Accession | Q15714 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 109677 Da |
| Gene ID | 8848 |
|---|---|
| Other Names | TSC22 domain family protein 1, Cerebral protein 2, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, Transforming growth factor beta-1-induced transcript 4 protein, TSC22D1, KIAA1994, TGFB1I4, TSC22 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TSC22. The exact sequence is proprietary. |
| Dilution | WB~~1:1000 ICC~~N/A IHC-P~~1:50~200 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TSC22D1 (HGNC:16826) |
|---|---|
| Function | Transcriptional repressor (PubMed:10488076). Acts on the C- type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta- induced transcription of COL1A2; via its interaction with TFE3 at E- boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:P62500}. Cell membrane; Peripheral membrane protein [Isoform 2]: Cytoplasm. Nucleus Mitochondrion |
| Tissue Location | Ubiquitously expressed in adult tissues (PubMed:26752201, PubMed:8651929). Expressed in the postmitotic epithelial compartment at the top of intestinal mucosal villi (PubMed:12468551). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
REFERENCES
Jay P.,et al.Biochem. Biophys. Res. Commun. 222:821-826(1996).
Ohta S.,et al.Eur. J. Biochem. 242:460-466(1996).
Dmitrenko V.V.,et al.Cyt. Genet. 30:41-47(1996).
Yazaki M.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Kawamata H.,et al.Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
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