癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC43A1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, ICC |
|---|---|
| Primary Accession | O75387 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61477 Da |
| Gene ID | 8501 |
|---|---|
| Other Names | Large neutral amino acids transporter small subunit 3, L-type amino acid transporter 3, Prostate cancer overexpressed gene 1 protein, Solute carrier family 43 member 1, SLC43A1 {ECO:0000312|EMBL:AAH016391} |
| Dilution | WB~~1:1000 ICC~~N/A |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SLC43A1 {ECO:0000312|EMBL:AAH01639.1} |
|---|---|
| Function | Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:12930836). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:12930836). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein. Note=Located in the apical plasma membrane of the podocyte foot processes (PubMed:19443642). Located in the plasma membrane of liver and skeletal muscle, and in the endoplasmic reticulum and in crystalline inclusions in pancreatic acinar cells (By similarity). {ECO:0000250|UniProtKB:Q8BSM7, ECO:0000269|PubMed:19443642} |
| Tissue Location | Ubiquitously expressed in fetus and adult (PubMed:9722952). Highest expression in adult pancreas, liver, skeletal muscle (PubMed:12930836, PubMed:9722952). In fetus, highest expression in liver and lower levels in kidney, and lung (PubMed:12930836) Exclusively expressed in the glomeruli along the glomerular capillary walls (PubMed:19443642). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.
REFERENCES
Cole K.A.,et al.Genomics 51:282-287(1998).
Babu E.,et al.J. Biol. Chem. 278:43838-43845(2003).
Chuaqui R.F.,et al.Urology 50:302-307(1997).
Skotheim R.I.,et al.Cancer Res. 62:2359-2364(2002).
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