癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MMD Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q15546 |
| Other Accession | Q719N3, Q9CQY7 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27667 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 23531 |
|---|---|
| Other Names | Monocyte to macrophage differentiation factor, Progestin and adipoQ receptor family member 11, Progestin and adipoQ receptor family member XI, MMD, PAQR11 |
| Target/Specificity | This MMD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MMD. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MMD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MMD (HGNC:7153) |
|---|---|
| Function | Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. |
| Cellular Location | Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein |
| Tissue Location | Exhibits relatively ubiquitous expression with preferential expression in mature (in vitro differentiated) macrophages. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MMD is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages.
REFERENCES
Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)
Rehli, M., et al. Biochem. Biophys. Res. Commun. 217(2):661-667(1995)
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