癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-COASY Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q13057 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 62329 Da |
| Gene ID | 80347 |
|---|---|
| Other Names | Bifunctional coenzyme A synthase; CoA synthase; NBP; POV-2 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human COASY. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | COASY (HGNC:29932) |
|---|---|
| Function | Bifunctional enzyme that catalyzes the fourth step of the coenzyme A biosynthetic pathway, the adenylation of 4'- phosphopantetheine, and the fifth step, the phosphorylation of dephospho-CoA to CoA. |
| Cellular Location | Cytoplasm, cytosol. Mitochondrion matrix. Note=The protein is mainly cytosolic and active in the cytosol (PubMed:40925986). Present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane (PubMed:24360804). |
| Tissue Location | Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Daugherty M.,et al.J. Biol. Chem. 277:21431-21439(2002).
Aghajanian S.,et al.Biochem. J. 365:13-18(2002).
Ota T.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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