癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-RAB30 Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q15771 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 23058 Da |
| Gene ID | 27314 |
|---|---|
| Other Names | Ras-related protein Rab-30 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human RAB30. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000) IHC~~1:100~500 |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RAB30 (HGNC:9770) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22188167). RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (PubMed:22188167). Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner (By similarity). Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection (PubMed:26771875). |
| Cellular Location | Membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans- Golgi network membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome membrane. Autolysosome membrane. Note=Localized to dynamic membranes fusing to and exiting from the Golgi apparatus (By similarity) Localized to group A Streptococcus (GAS)-containing autophagosome to autolysosome in GAS-infected epithelial cells (PubMed:26771875). Also colocalized with a starvation-induced autophagosome although not required for autophagosome formation during starvation (PubMed:26771875). {ECO:0000250|UniProtKB:Q923S9, ECO:0000269|PubMed:26771875} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Chen D.,et al.Gene 174:129-134(1996).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Daub H.,et al.Mol. Cell 31:438-448(2008).
Olsen J.V.,et al.Sci. Signal. 3:RA3-RA3(2010).
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Cat# AP51838
