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>   首页   >   产品   >   一抗   >   代谢   >   NCKX1 Antibody   

NCKX1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC
Primary Accession O60721
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 121374 Da
Additional Information
Gene ID 9187
Other Names Sodium/potassium/calcium exchanger 1, Na(+)/K(+)/Ca(2+)-exchange protein 1, Retinal rod Na-Ca+K exchanger, Solute carrier family 24 member 1, SLC24A1, KIAA0702, NCKX1
Dilution WB~~1:1000
ICC~~N/A
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name SLC24A1 {ECO:0000303|PubMed:20850105, ECO:0000312|HGNC:HGNC:10975}
Function Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:26631410). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness (PubMed:20850105). Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (PubMed:20850105).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

REFERENCES

Tucker J.E.,et al.Hum. Genet. 103:411-414(1998).
Tucker J.E.,et al.Invest. Ophthalmol. Vis. Sci. 39:435-440(1998).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
McKiernan C.J.,et al.J. Biol. Chem. 274:38177-38182(1999).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).

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