CD106 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB |
---|---|
Primary Accession | P19320 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 81276 Da |
Gene ID | 7412 |
---|---|
Other Names | Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, INCAM-100, CD106, VCAM1, L1CAM |
Dilution | WB~~1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | VCAM1 |
---|---|
Function | Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Also serves as a quality- control checkpoint for entry into bone marrow by providing a 'don't- eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567). |
Cellular Location | [Vascular cell adhesion protein 1]: Cell membrane; Single-pass type I membrane protein |
Tissue Location | Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
REFERENCES
Osborn L.,et al.Cell 59:1203-1211(1989).
Polte T.,et al.Nucleic Acids Res. 18:5901-5901(1990).
Hession C.,et al.J. Biol. Chem. 266:6682-6685(1991).
Cybulsky M.I.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:7859-7863(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问,联系:0512-88856768 tech-china@abcepta.com.