癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-GPR179 Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q6PRD1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 257363 Da |
| Gene ID | 440435 |
|---|---|
| Other Names | GPR158L; GPR158L1; Probable G-protein coupled receptor 179; Probable G-protein coupled receptor 158-like 1; GPR158-like |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GPR179. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GPR179 {ECO:0000303|PubMed:24084093, ECO:0000312|HGNC:HGNC:31371} |
|---|---|
| Function | Orphan receptor involved in vision (PubMed:22325362, PubMed:24084093). Required for signal transduction through retinal depolarizing bipolar cells (PubMed:22325362). Acts as an atypical G protein-coupled receptor that recruits and regulates the R7 group RGS- GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:E9PY61}; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250|UniProtKB:E9PY61}; Multi-pass membrane protein. Cell projection, dendrite Note=Specifically localizes to the tips of retinal ON-bipolar dendrites. |
| Tissue Location | Expressed in the retina. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Bonner T.I.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Audo I.,et al.Am. J. Hum. Genet. 90:321-330(2012).
Peachey N.S.,et al.Am. J. Hum. Genet. 90:331-339(2012).
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