癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ADRB1 Rabbit pAb
ADRB1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P08588 |
| Reactivity | Rat, Human, Mouse |
| Predicted | Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51224 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ADRB1 |
| Epitope Specificity | 181-250/477 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Beta-adrenergic receptors (Beta-1 adrenoreceptor) mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Subcellular location cell membrane; Multi-pass membrane protein. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Belongs to the G-protein coupled receptor 1 family. |
| Gene ID | 153 |
|---|---|
| Other Names | Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor, ADRB1 (HGNC:285), ADRB1R, B1AR |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1ug/Test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADRB1 (HGNC:285) |
|---|---|
| Synonyms | ADRB1R, B1AR |
| Function | G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway (PubMed:10212248, PubMed:12391161, PubMed:15358775). Binds epinephrine and norepinephrine with approximately equal affinity (PubMed:33093660). Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2 (PubMed:12391161). As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction (PubMed:11052857). Also delivers proapoptotic signals in cardiomyocytes (By similarity). Involved in the regulation of sleep/wake behaviors (PubMed:11854867, PubMed:31473062). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P18090}; Multi-pass membrane protein Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity) Localized at the plasma membrane (By similarity). Found in the Golgi upon GOPC overexpression (PubMed:15358775). Localized to early endosomes during endocytic trafficking (PubMed:21540189) {ECO:0000250|UniProtKB:P18090, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:21540189} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
REFERENCES
Frielle T.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:7920-7924(1987).
Moore J.D.,et al.Hum. Mutat. 14:271-271(1999).
Deloukas P.,et al.Nature 429:375-381(2004).
Pak Y.,et al.Mol. Cell. Biol. 22:7942-7952(2002).
He J.,et al.J. Biol. Chem. 279:50190-50196(2004).
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¥ 1,250.00
Cat# AP52101
