癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CMA1 Rabbit pAb
CMA1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P23946 |
| Reactivity | Rat, Human, Mouse |
| Predicted | Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27325 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CMA1 |
| Epitope Specificity | 28-42/247 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Secreted. Cytoplasmic granule. Note=Mast cell granules. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase and proteolytic tryptase. Human Mast Cell Chymase is considered to be an important marker of mast cells as well as an important mediator of inflammation. |
| Gene ID | 1215 |
|---|---|
| Other Names | Chymase, 3.4.21.39, Alpha-chymase, Mast cell protease I, CMA1, CYH, CYM |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CMA1 |
|---|---|
| Synonyms | CYH, CYM |
| Function | Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. |
| Cellular Location | Secreted. Cytoplasmic granule. Note=Mast cell granules |
| Tissue Location | Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
REFERENCES
Caughey G.H.,et al.J. Biol. Chem. 266:12956-12963(1991).
Urata H.,et al.J. Biol. Chem. 266:17173-17179(1991).
Schechter N.M.,et al.J. Immunol. 152:4062-4069(1994).
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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