癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FOXM1 Rabbit pAb
FOXM1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
| Primary Accession | Q08050 |
|---|---|
| Reactivity | Human |
| Predicted | Rat, Dog, Mouse, Rabbit, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 84283 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FOXM1 |
| Epitope Specificity | 301-400/801 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The Forkhead Box (Fox) proteins are an extensive family of transcription factors that share homology in the winged helix DNA-binding domain and the members of which play essential roles in a diverse range of developmental processes as well as cellular proliferation, differentiation, and longevity. The Fox factors are especially important in the establishment of the body axis and the development of tissues from all three germ layers. FOXM1 is also overexpressed in many human cancers and has a role in tumorigenesis. |
| Gene ID | 2305 |
|---|---|
| Other Names | Forkhead box protein M1, Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 forkhead homolog 11, HFH-11, HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, Transcription factor Trident, Winged-helix factor from INS-1 cells, FOXM1, FKHL16, HFH11, MPP2, WIN |
| Dilution | ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FOXM1 |
|---|---|
| Synonyms | FKHL16, HFH11, MPP2, WIN |
| Function | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). |
| Cellular Location | [Isoform 1]: Nucleus [Isoform 4]: Cytoplasm |
| Tissue Location | Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors Not expressed in resting cells. Isoform 2 is highly expressed in testis |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
REFERENCES
Ye H.,et al.Mol. Cell. Biol. 17:1626-1641(1997).
Yao K.-M.,et al.J. Biol. Chem. 272:19827-19836(1997).
Westendorf J.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:714-718(1994).
Tan Y.,et al.Mol. Cell. Biol. 27:1007-1016(2007).
Fu Z.,et al.Nat. Cell Biol. 10:1076-1082(2008).
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