癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OCLN Rabbit pAb
OCLN Rabbit pAb
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q61146 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog, Pig, Horse, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59000 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse OCLN |
| Epitope Specificity | 431-522/522 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Multi-pass membrane protein. Cell junction, tight junction. |
| SIMILARITY | Belongs to the ELL/occludin family. Contains 1 MARVEL domain. |
| SUBUNIT | Interacts with TJP1/ZO1 and with VAPA. |
| Post-translational modifications | Phosphorylated upon DNA damage, probably by ATM or ATR. Dephosphorylated by PTPRJ. May be phosphorylated by PKC during translocation to cell-cell contacts. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described. [provided by RefSeq]. |
| Gene ID | 18260 |
|---|---|
| Other Names | Occludin, Ocln, Ocl |
| Target/Specificity | Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis. |
| Dilution | WB=1:500-2000,Flow-Cyt=2 µg/Test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ocln |
|---|---|
| Synonyms | Ocl |
| Function | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, tight junction |
| Tissue Location | Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in the testis, kidney, lung, liver and brain. Not detected in skeletal muscle, spleen and heart |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described. [provided by RefSeq].
REFERENCES
Ando-Akatsuka Y.,et al.J. Cell Biol. 133:43-47(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Saitou M.,et al.Mol. Biol. Cell 11:4131-4142(2000).
Andreeva A.Y.,et al.J. Biol. Chem. 276:38480-38486(2001).
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