癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC25A19 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 2
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HC21 |
| Other Accession | Q5IS35 |
| Reactivity | Human, Mouse |
| Predicted | Monkey, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35511 Da |
| Antigen Region | 236-263 aa |
| Gene ID | 60386 |
|---|---|
| Other Names | Mitochondrial thiamine pyrophosphate carrier, Mitochondrial uncoupling protein 1, Solute carrier family 25 member 19, SLC25A19, DNC, MUP1 |
| Target/Specificity | This SLC25A19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human SLC25A19. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC25A19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC25A19 (HGNC:14409) |
|---|---|
| Function | Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient. |
| Cellular Location | Mitochondrion membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in all tissues examined except for placenta. Highest levels in colon, kidney, lung, testis, spleen, and brain. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SLC25A19 encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria.
REFERENCES
Spiegel, R., et al. Ann. Neurol. 66(3):419-424(2009)
Kang, J., et al. Mitochondrion 8(2):103-108(2008)
Lindhurst, M.J., et al. Proc. Natl. Acad. Sci. U.S.A. 103(43):15927-15932(2006)
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