癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC25A19 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9HC21 |
| Other Accession | Q9HC21 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35511 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SLC25A19 |
| Epitope Specificity | 1-100/320 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SIMILARITY | Belongs to the mitochondrial carrier (TC 2.A.29) family. Contains 3 Solcar repeats. |
| DISEASE | The disease is caused by mutations affecting the gene represented in this entry. Disease description:A disorder characterized by severe congenital microcephaly and severe 2-ketoglutaric aciduria leading to death within the first year. The disease is caused by mutations affecting the gene represented in this entry. Disease description:A disease characterized by recurrent episodes of flaccid paralysis and encephalopathy associated with bilateral striatal necrosis and chronic progressive polyneuropathy. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Gene ID | 60386 |
|---|---|
| Other Names | DNC; MCPHA; MTPPT; MUP1; THMD3; THMD4; TPC; TPC_HUMAN; SLC25A19; Mitochondrial thiamine pyrophosphate transporter (MTPPT); Mitochondrial uncoupling protein 1; Solute carrier family 25 member 19; solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19; microcephaly, Amish; solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19; Mitochondrial thiamine pyrophosphate carrier; Deoxynucleotide carrier |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC25A19 (HGNC:14409) |
|---|---|
| Function | Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient. |
| Cellular Location | Mitochondrion membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in all tissues examined except for placenta. Highest levels in colon, kidney, lung, testis, spleen, and brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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