癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Rab2 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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- 背景知识
| Primary Accession | P61019 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 23546 Da |
| Gene ID | 5862 |
|---|---|
| Other Names | 9330148M11Rik;C80220;GTP binding protein;LHX;OTTMUSP00000004796;RAB2;RAB2 member RAS oncogene family;RAB2A;RAB2A, member RAS oncogene family;RAB2A_HUMAN;Ras related protein Rab 2A;RAS-associated protein RAB2;Ras-related protein Rab-2A;RP23-183L6.1;Small GTP binding protein RAB2A. |
| Format | Ascites |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | RAB2A (HGNC:9763) |
|---|---|
| Synonyms | RAB2 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915). |
| Cellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor; Cytoplasmic side Melanosome. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P53994}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P53994}; Lipid-anchor; Cytoplasmic side Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250|UniProtKB:P53994, ECO:0000269|PubMed:17081065} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Required for protein transport from the endoplasmic reticulum to the Golgi complex.
REFERENCES
Tachibana K.,et al.Nucleic Acids Res. 16:10368-10368(1988).
Zahraoui A.,et al.J. Biol. Chem. 264:12394-12401(1989).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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