癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LRRFIP1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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| Primary Accession | Q32MZ4 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 89253 Da |
| Gene ID | 9208 |
|---|---|
| Other Names | FLAP1;FLIIAP 1;GC binding factor 2;GCF2;HUFI1;Leucine rich repeat (in FLII) interacting protein 1;Leucine rich repeat flightless interacting protein 1;LRR FLII interacting protein 1;LRRFIP 1;Lrrfip1;MGC10947;MGC119738;MGC119739;NEDD8 conjugating enzyme;TAR RNA interacting protein;TAR RNA-interacting protein;Transcription factor 9 like;TRIP. |
| Format | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.09% (W/V) sodium azide, 50%,glycerol |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LRRFIP1 |
|---|---|
| Synonyms | GCF2, TRIP |
| Function | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
| Cellular Location | Nucleus. Cytoplasm. |
| Tissue Location | Ubiquitously expressed. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
REFERENCES
Reed A.L.,et al.J. Biol. Chem. 273:21594-21602(1998).
Wilson S.A.,et al.Nucleic Acids Res. 26:3460-3467(1998).
Hillier L.W.,et al.Nature 434:724-731(2005).
Fong K.S.K.,et al.Genomics 58:146-157(1999).
Khachigian L.M.,et al.Circ. Res. 84:1258-1267(1999).
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