癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ATIC Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application 
| WB |
|---|---|
| Primary Accession | P31939 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 64616 Da |
| Gene ID | 471 |
|---|---|
| Other Names | 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase;5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase;5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase;5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase;AICAR;AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme;AICAR transformylase;AICARFT;AICARFT/IMPCHASE;ATIC; Bifunctional purine biosynthesis protein PURH;FLJ93545;IMP cyclohydrolase;IMP synthase;IMP synthetase;IMPCHASE;Inosinicase;OK/SW-cl.86; Phosphoribosylaminoimidazolecarboxamide formyltransferase; Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase;PUR9_HUMAN; PURH. |
| Dilution | WB~~1:1000 |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ATIC (HGNC:794) |
|---|---|
| Function | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113} |
| Tissue Location | Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
REFERENCES
Rayl E.A.,et al.J. Biol. Chem. 271:2225-2233(1996).
Yamauchi M.,et al.DNA Res. 2:269-275(1995).
Sugita T.,et al.J. Biochem. 122:309-313(1997).
Shichijo S.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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