癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Keratin(50-60kDa) Antibody
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P13647 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 62378 Da |
| Gene ID | 3852 |
|---|---|
| Other Names | 58 kDa cytokeratin; CK 5; CK-5; CK5; Cytokeratin-5; Cytokeratin5; DDD; DDD1; EBS 2; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5_HUMAN; K5; Keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); Keratin 5; Keratin; keratin complex 2, basic, gene 5; Keratin Type II Cytoskeletal 5; keratin, type II cytoskeletal 5; Keratin-5; Keratin5; KRT 5; KRT 5A; KRT5; KRT5A; type II cytoskeletal 5; Type-II keratin Kb5. |
| Dilution | WB~~1:2000 |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT5 (HGNC:6442) |
|---|---|
| Function | Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Together with its obligate type I partner KRT14, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis (PubMed:1372711, PubMed:1694855). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in corneal epithelium (at protein level) (PubMed:26758872). Expressed in keratinocytes (at protein level) (PubMed:20128788, PubMed:31302245). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Eckert R.L.,et al.DNA 7:337-345(1988).
Lersch R.,et al.Mol. Cell. Biol. 9:3685-3697(1989).
Whittock N.V.,et al.Biochem. Biophys. Res. Commun. 274:149-152(2000).
Lersch R.,et al.Mol. Cell. Biol. 8:486-493(1988).
Xu Z.,et al.Clin. Exp. Dermatol. 29:74-76(2004).
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