癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
XRCC1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application 
| WB |
|---|---|
| Primary Accession | P18887 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 69498 Da |
| Gene ID | 7515 |
|---|---|
| Other Names | DNA repair protein XRCC1;RCC;X ray repair complementing defective repair in chinese hamster;X ray repair complementing defective repair in chinese hamster cells 1;X ray Repair Complementing Defective Repair in Chinese Hamster Cells;X ray repair cross complementing protein 1;X ray repair, complementing defective, repair in Chinese hamster;X-ray repair cross-complementing protein 1;XRCC 1;Xrcc1;XRCC1_HUMAN. |
| Dilution | WB~~1:1000 |
| Format | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | XRCC1 {ECO:0000303|PubMed:2247054, ECO:0000312|HGNC:HGNC:12828} |
|---|---|
| Function | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP- ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). |
| Cellular Location | Nucleus. Chromosome Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage (PubMed:28002403). Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814) |
| Tissue Location | Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
REFERENCES
Thompson L.H.,et al.Mol. Cell. Biol. 10:6160-6171(1990).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Whitehouse C.J.,et al.Cell 104:107-117(2001).
Sano Y.,et al.Ann. Neurol. 55:241-249(2004).
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