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TTLL11 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q8NHH1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 79091 Da |
| Antigen Region | 399-427 aa |
| Gene ID | 158135 |
|---|---|
| Other Names | Tubulin polyglutamylase TTLL11, 6---, Tubulin--tyrosine ligase-like protein 11, TTLL11, C9orf20 |
| Target/Specificity | This TTLL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-427 amino acids from the C-terminal region of human TTLL11. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TTLL11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TTLL11 (HGNC:18113) |
|---|---|
| Synonyms | C9orf20 |
| Function | Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side- chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta- tail (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A4Q9F4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A4Q9F4} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TTLL11 is polyglutamase which preferentially modifies alpha-tubulin. It is involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step.
REFERENCES
Janke, C., et al. Science 308(5729):1758-1762(2005)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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