癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
YLAT2 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q92536 |
| Other Accession | NP_003974.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56828 Da |
| Antigen Region | 487-515 aa |
| Gene ID | 9057 |
|---|---|
| Other Names | Y+L amino acid transporter 2, Cationic amino acid transporter, y+ system, Solute carrier family 7 member 6, y(+)L-type amino acid transporter 2, Y+LAT2, y+LAT-2, SLC7A6 (HGNC:11064) |
| Target/Specificity | This YLAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-515 amino acids from the C-terminal region of human YLAT2. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | YLAT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC7A6 (HGNC:11064) |
|---|---|
| Function | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in normal fibroblasts and those from LPI patients (PubMed:11078698). Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines (PubMed:11742806, PubMed:14603368, PubMed:15280038, PubMed:17197568, PubMed:17329401) Expressed in brain, heart, testis, kidney, small intestine and parotis (PubMed:10903140). Highly expressed in T lymphocytes (PubMed:31705628) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This protein involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. It requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. It also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. It plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It involved in the transport of L-arginine in monocytes and reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
REFERENCES
Sekine, Y., et al. J. Am. Soc. Nephrol. 20(7):1586-1596(2009)
Broer, S. Physiol. Rev. 88(1):249-286(2008)
Xu, D., et al. Mol. Cell Proteomics 4(8):1061-1071(2005)
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