癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CDK11B Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | P21127 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 92620 Da |
| Gene ID | 984 |
|---|---|
| Other Names | Cyclin-dependent kinase 11B, 2.7.11.22, Cell division cycle 2-like protein kinase 1, CLK-1, Cell division protein kinase 11B, Galactosyltransferase-associated protein kinase p58/GTA, PITSLRE serine/threonine-protein kinase CDC2L1, p58 CLK-1, CDK11B, CDC2L1, CDK11, PITSLREA, PK58 |
| Dilution | WB~~ 1:1000 |
| Format | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CDK11B |
|---|---|
| Synonyms | CDC2L1, CDK11, PITSLREA, PK58 |
| Function | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity- dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expressed ubiquitously. Some evidence of isoform- specific tissue distribution. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
REFERENCES
Bunnell B.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7467-7471(1990).
Bunnell B.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:2612-2612(1991).
Eipers P.G.,et al.Genomics 13:613-621(1992).
Xiang J.,et al.J. Biol. Chem. 269:15786-15794(1994).
Gururajan R.,et al.Genome Res. 8:929-939(1998).
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