癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-GTF2IRD1 Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC, IP |
|---|---|
| Primary Accession | Q9UHL9 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 106057 Da |
| Gene ID | 9569 |
|---|---|
| Other Names | CREAM1; GTF3; MUSTRD1; RBAP2; WBSCR11; WBSCR12; General transcription factor II-I repeat domain-containing protein 1; GTF2I repeat domain-containing protein 1; General transcription factor III; MusTRD1/BEN; Muscle TFII-I repeat domain-containing protein 1; Slow-muscle-fiber enhancer-binding protein; USE B1-binding protein; Williams-Beuren syndrome chromosomal region 11 protein; Williams-Beuren syndrome chromosomal region 12 protein |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GTF2IRD1. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000) IHC~~1:100~500 IP~~N/A |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GTF2IRD1 |
|---|---|
| Synonyms | CREAM1, GTF3, MUSTRD1, RBAP2, WBSCR11, W |
| Function | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow- twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
O'Mahoney J.V.,et al.Mol. Cell. Biol. 18:6641-6652(1998).
Osborne L.R.,et al.Genomics 57:279-284(1999).
Tassabehji M.,et al.Eur. J. Hum. Genet. 7:737-747(1999).
Franke Y.,et al.Cytogenet. Cell Genet. 86:296-304(1999).
Yan X.,et al.Biochem. J. 345:749-757(2000).
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Cat# AP53349
