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>   首页   >   产品   >   一抗   >   其他   >   Anti-ENDOG Antibody   

Anti-ENDOG Antibody

     
  • 1 - Anti-ENDOG Antibody AP53667
    Western blot analysis of ENDOG expression in NCIH292 (A), HepG2 (B), Raw264.7 (C), PC12 (D) whole cell lysates.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q14249
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 32620 Da
Additional Information
Gene ID 2021
Other Names Endonuclease G, mitochondrial; Endo G
Target/Specificity Recognizes endogenous levels of ENDOG protein.
Dilution WB~~1/500 - 1/1000
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ENDOG
Function Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA (PubMed:25355512). The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (By similarity). Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs (By similarity). Promotes conservative recombination when the DNA is 5hmC-modified (PubMed:25355512). Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response (PubMed:33473107). GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (PubMed:33473107). Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (PubMed:29719607).
Cellular Location Mitochondrion.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Rabbit polyclonal antibody to ENDOG

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