Anti-LDLRAD3 Antibody

Western blot analysis of LDLRAD3 expression in HEK293T (A), A549 (B), PC12 (C), MEF (D), LO2 (E) whole cell lysates.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	Q86YD5
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Calculated MW	37419 Da

Additional Information
Gene ID	143458
Other Names	Low-density lipoprotein receptor class A domain-containing protein 3
Target/Specificity	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LDLRAD3. The exact sequence is proprietary.
Dilution	WB~~1/500 - 1/1000
Format	Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
Storage	Store at -20 °C.Stable for 12 months from date of receipt

Protein Information
Name	LDLRAD3 (HGNC:27046)
Synonyms	LRAD3
Function	May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353).
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver