Anti-NRBP1 Antibody

Western blot analysis of NRBP1 expression in Jurkat (A), HepG2 (B) whole cell lysates.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	Q9UHY1
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Calculated MW	59845 Da

Additional Information
Gene ID	29959
Other Names	BCON3; NRBP; Nuclear receptor-binding protein
Target/Specificity	Recognizes endogenous levels of NRBP1 protein.
Dilution	WB~~1/500 - 1/1000
Format	Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
Storage	Store at -20 °C.Stable for 12 months from date of receipt

Protein Information
Name	NRBP1
Synonyms	BCON3 {ECO:0000312\|EMBL:AAF21967.1}, NRB
Function	Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397).
Cellular Location	Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia
Tissue Location	Ubiquitously expressed in all tissues examined with high levels in the testis.