癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-GON4L Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q3T8J9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 248620 Da |
| Gene ID | 54856 |
|---|---|
| Other Names | GON4; KIAA1606; GON-4-like protein; GON-4 homolog |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GON4L. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GON4L {ECO:0000303|PubMed:25339177, ECO:0000312|HGNC:HGNC:25973} |
|---|---|
| Function | Acts as a key transcription regulator of histones (PubMed:25339177, PubMed:40516528, PubMed:40516529). Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF (PubMed:25339177). Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription (PubMed:40516528, PubMed:40516529). Also acts as a transcription corepressor, as part of a complex with YY1, SIN3A and HDAC1 (By similarity). Required for B- cell lymphopoiesis (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810}. Chromosome Note=Localizes to histone locus bodies (HLB) |
| Tissue Location | Widely expressed.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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