癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTAFR Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P25105 |
| Other Accession | NP_001158195.1, NP_000943.1, NP_001158194.1, NP_001158193.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39203 Da |
| Antigen Region | 286-312 aa |
| Gene ID | 5724 |
|---|---|
| Other Names | Platelet-activating factor receptor, PAF-R, PAFr, PTAFR, PAFR |
| Target/Specificity | This PTAFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-312 amino acids from the C-terminal region of human PTAFR. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTAFR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTAFR |
|---|---|
| Synonyms | PAFR |
| Function | Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PTAFR shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.
REFERENCES
Davila, S., et al. Genes Immun. (2010) In press :
Hirota, N., et al. J. Biol. Chem. 285(8):5931-5940(2010)
Kaneko, K., et al. J. Invest. Dermatol. 129(11):2567-2573(2009)
Melnikova, V.O., et al. J. Biol. Chem. 284(42):28845-28855(2009)
Poisson, C., et al. J. Immunol. 183(4):2747-2757(2009)
Sugimoto, T., et al. Biochem. Biophys. Res. Commun. 189(2):617-624(1992)
Seyfried, C.E., et al. Genomics 13(3):832-834(1992)
Kunz, D., et al. J. Biol. Chem. 267(13):9101-9106(1992)
Shukla, S.D. FASEB J. 6(6):2296-2301(1992)
Ye, R.D., et al. Biochem. Biophys. Res. Commun. 180(1):105-111(1991)
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