癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-CSN5A/B Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8LAZ7 |
| Other Accession | Q9FVU9 |
| Reactivity | Arabidopsis thaliana |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39731 Da |
| Gene ID | 838899 |
|---|---|
| Other Names | AJH1; CSN5B; COP9 signalosome complex subunit 5a; Signalosome subunit 5a; Jun activation domain-binding homolog 1; AJH2; CSN5A; COP9 signalosome complex subunit 5b; Signalosome subunit 5b; Jun activation domain-binding homolog 2 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of arabidopsis thaliana CSN5A/B. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/2000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CSN5A {ECO:0000303|PubMed:23424245} |
|---|---|
| Function | Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Involved in CSN's deneddylation/derubylation activity (PubMed:15486099). Required for the deneddylation of all cullins (PubMed:15923347, PubMed:17307927). Essential for the structural integrity of the CSN holocomplex (PubMed:17307927). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Ubiquitously expressed. Highly expressed in flowers and roots. Expressed at lower level in seedlings and siliques |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
