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ACY3 Rabbit pAb
ACY3 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96HD9 |
| Predicted | Rat, Human, Mouse, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35241 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ACY 3 |
| Epitope Specificity | 221-319/319 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ACY3 belongs to the aspA/astE family. Aspartoacylase subfamily. Catalytic activity: N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate. Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. |
| Gene ID | 91703 |
|---|---|
| Other Names | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), 3.5.1.114, Acylase III, Aminoacylase-3, ACY-3, Aspartoacylase-2, Hepatitis C virus core-binding protein 1, HCBP1, HCV core-binding protein 1, ACY3, ASPA2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ACY3 |
|---|---|
| Synonyms | ASPA2 |
| Function | Deacetylates N-acetyl aromatic amino acids and mercapturic acids (N-acetyl-L-cysteine-S-conjugates), including halogenated mercapturic acids derived from the metabolism of environmental contaminants such as trichloroethylene, making it a key enzyme in the processing of both endogenous and xenobiotic compounds. In neurons and blood vessels, deacetylates the mercapturates of 4-hydroxy-2-nonenal (4HNE) and acrolein (ACR), two highly reactive lipid peroxidation products; the resulting deacetylated products can then be transformed into toxic compounds by beta-lyase. |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:Q91XE4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q91XE4}. Cytoplasm {ECO:0000250|UniProtKB:Q91XE4}. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. {ECO:0000250|UniProtKB:Q91XE4} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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