癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MTP18 Rabbit pAb
MTP18 Rabbit pAb
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Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9UDX5 |
| Reactivity | Rat |
| Predicted | Pig, Dog, Human, Mouse, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 18010 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MTP18 |
| Epitope Specificity | 41-140/166 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Mitochondrion inner membrane; Multi-pass membrane protein (Probable). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]).[supplied by OMIM, Mar 2008] |
| Gene ID | 51537 |
|---|---|
| Other Names | Mitochondrial fission process protein 1, Mitochondrial 18 kDa protein, MTP18, MTFP1, MTP18 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MTFP1 |
|---|---|
| Synonyms | MTP18 |
| Function | Plays a role in the regulation of mitochondrial morphology (PubMed:15155745, PubMed:15985469). Inhibits mitochondrial fusion by creating a non-fusogenic lipid environment which affects OPA1 oligomerization and its subsequent capacity to drive fusion (PubMed:38851188). This prevents defective inner mitochondrial membrane (IMM) subdomains from fusing with other mitochondria, facilitating their segregation into small MTFP1-enriched mitochondria (SMEM) which are targeted for autophagic degradation (PubMed:38851188, PubMed:41398051). This IMM quality control mechanism controls mitochondrial DNA levels (PubMed:38851188). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein. Note=Assembles into discrete subdomains known as small MTFP1-enriched mitochondria (SMEM). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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