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MYRIP Rabbit pAb
MYRIP Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8NFW9 |
| Predicted | Rat, Pig, Human, Mouse, Rabbit, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 95706 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MYRIP/SLAC2-C |
| Epitope Specificity | 101-200/859 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. In pre- and post-synaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Slac2-c is a Rab effector protein that is expressed in a variety of tissues including brain, heart, skin and liver. Found in the basal microvilli of retinal pigment cells and in pre- and post-synaptic areas in photoreceptor cells , Slac2-c is involved in melanosome transport and functions to link Rab 27a with the actin-based motor proteins Myosin Va and Myosin VIIa. Once linked, the Myosins are able to transport Rab 27a to retinal melanosomes, thereby linking the actin cytoskeleton with the melanosome membrane. Slac2-c contains one FYVE-type zinc finger and one Rab-binding domain and is able to bind actin-like proteins through its conserved C-terminal region. Additionally, Slac2-c is thought to regulate the final steps of insulin exocytosis by mediating the interaction of secretory granules with the cortical actin cytoskeleton. |
| Gene ID | 25924 |
|---|---|
| Other Names | Rab effector MyRIP, Exophilin-8, Myosin-VIIa- and Rab-interacting protein, Synaptotagmin-like protein lacking C2 domains C, SlaC2-c, Slp homolog lacking C2 domains c, MYRIP, SLAC2C |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MYRIP |
|---|---|
| Synonyms | SLAC2C |
| Function | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8K3I4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TNY7} Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q7TNY7} Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments {ECO:0000250|UniProtKB:Q7TNY7} |
| Tissue Location | Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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