癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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DUOX1 Rabbit pAb
DUOX1 Rabbit pAb
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9NRD9 |
| Reactivity | Human |
| Predicted | Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 177235 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DUOX1 |
| Epitope Specificity | 1-100/1551 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Dual oxidase 1 (DUOX1), a homolog of glycoprotein p91Phox, is expressed in airway epithelium and generates reactive oxygen species (ROS). DUOX1 is a multi-pass membrane protein predominantly expressed in thyrocytes and tracheal surface epithelial cells, as well as thyroid, trachea and bronchium. DUOX1 generates hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. It is also involved in thyroid hormone synthesis and lactoperoxidase-mediated antimicrobial defense in mucosa. DUOX1, which also plays a role in mucin expression, is widely expressed in fetal tissues. |
| Gene ID | 53905 |
|---|---|
| Other Names | Dual oxidase 1 {ECO:0000312|HGNC:HGNC:3062}, 1.-.-.-, 1.11.1.-, 1.6.3.1, Large NOX 1, Long NOX 1, NADPH thyroid oxidase 1, Thyroid oxidase 1, DUOX1 (HGNC:3062) |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DUOX1 (HGNC:3062) |
|---|---|
| Function | Generates hydrogen peroxide (H2O2) which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO (PubMed:10806195, PubMed:15972824). Plays a role in thyroid hormone synthesis (PubMed:10806195). Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa (PubMed:12824283). Antimicrobial agent hypothiocyanite (OSCN-), which is produced by LPO from DUOX1-derived H2O2, promotes influenza virus inactivation by reducing viral binding to and entry into host cells (PubMed:34168077). Promotes antiviral immunity by increasing airway cytokine levels, promoting innate immune cell recruitment and reducing airway epithelial cell apoptosis (By similarity). In response to bacterial stimuli, activated by ATP and promotes EGFR/ERK signaling, ADAM17 activation, and EGFR ligand shedding, leading to enhanced CXCL8/IL8 expression and secretion in airway epithelia (PubMed:19386603). Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation (PubMed:34784249). In addition to its oxidase activity, has also been shown to have peroxidase activity through its N-terminal peroxidase-like domain (PubMed:11514595). However, another study showed that the isolated peroxidase-like domain does not bind heme and has no intrinsic peroxidase activity (PubMed:19460756). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells. |
| Tissue Location | Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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