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Neuron navigator 1 Rabbit pAb
Neuron navigator 1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8NEY1 |
| Predicted | Rat, Pig, Dog, Human, Mouse, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 202472 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Neuron navigator 1 |
| Epitope Specificity | 1426-1475/1877 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton. Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Neuron navigator 1 is a 1877 amino acid cytoplasmic protein that is involved in neuronal migration. Neuron navigtor 1 is widely expressed at low levels, though highest expression is found in both adult and fetal nervous tissue. Through interaction with tubulin, Neuron navigator 1 associates with a subset of mirotubule plus ends present in the growth cone. Overexpression of Neuron navigator 1 leads to microtubule bundling, whereas a reduction of its levels causes loss of directionality in the migration of pontine cell leading processes. There are seven isoforms of Neuron navigator 1 that are produced as a result of alternative splicing events. |
| Gene ID | 89796 |
|---|---|
| Other Names | Neuron navigator 1, Pore membrane and/or filament-interacting-like protein 3, Steerin-1, Unc-53 homolog 1, unc53H1, NAV1, KIAA1151, KIAA1213, POMFIL3, STEERIN1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NAV1 |
|---|---|
| Synonyms | KIAA1151, KIAA1213, POMFIL3, STEERIN1 |
| Function | May be involved in neuronal migration. |
| Cellular Location | Cytoplasm, cytoskeleton. Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity). |
| Tissue Location | Broadly expressed at low levels (PubMed:12062803, PubMed:12079279, PubMed:15158073). Expressed at high levels in heart, skeletal muscle, placenta and possibly in pancreas and liver (PubMed:12062803, PubMed:12079279, PubMed:15158073) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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