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Aph-1b Rabbit pAb
Aph-1b Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8WW43 |
| Predicted | Rat, Pig, Dog, Human, Mouse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28460 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Aph-1b |
| Epitope Specificity | 51-150/257 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Multi-pass membrane protein |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Anterior pharynx defective 1 (Aph-1) is a polytopic, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex. This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, including the beta-Amyloid precursor protein, and is involved in multiple neurodevelopmental signaling pathways. Aph-1b and Aph-1a are splice variants of Aph-1. Aph-1b specifically lacks exon 4, which encodes for the entire fourth transmembrane domain, causing the protein to be destabilized. Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, however deficiency of Aph-1b does not; thus, Aph-1b may execute redundant functions in the cell. Aph-1b expression and Gamma-secretase activity may be implicated in neurodevelopmental disorders, such as schizophrenia. |
| Gene ID | 83464 |
|---|---|
| Other Names | Gamma-secretase subunit APH-1B, APH-1b, Aph-1beta, Presenilin-stabilization factor-like, APH1B, PSFL |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | APH1B |
|---|---|
| Synonyms | PSFL |
| Function | Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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