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NPEPPS Rabbit pAb
NPEPPS Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P55786 |
| Reactivity | Mouse |
| Predicted | Human, Rat, Dog, Pig, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 103276 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NPEPPS |
| Epitope Specificity | 201-300/919 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the peptidase M1 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Puromycin-sensitive aminopeptidase is a 100kDa zinc metallopeptidase which degrades neuropeptides by removing amino acid residues from the amino-terminus. The protein is the most abundant aminopeptidase in the brain, however it is not exclusive to that organ. It is localized primarily in the cytoplasm, and plays a role in the metabolism of neuropeptides in nerve terminals and synaptic clefts. The human PSA gene maps to chromosome 17q 2-32. |
| Gene ID | 9520 |
|---|---|
| Other Names | Puromycin-sensitive aminopeptidase, PSA, 3.4.11.14, Cytosol alanyl aminopeptidase, AAP-S, NPEPPS, PSA |
| Target/Specificity | Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level). |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | NPEPPS |
|---|---|
| Synonyms | PSA |
| Function | Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. |
| Cellular Location | Cytoplasm, cytosol. Nucleus |
| Tissue Location | Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Puromycin-sensitive aminopeptidase is a 100kDa zinc metallopeptidase which degrades neuropeptides by removing amino acid residues from the amino-terminus. The protein is the most abundant aminopeptidase in the brain, however it is not exclusive to that organ. It is localized primarily in the cytoplasm, and plays a role in the metabolism of neuropeptides in nerve terminals and synaptic clefts. The human PSA gene maps to chromosome 17q 2-32.
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