癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CCDC146 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IYE0 |
| Other Accession | NP_065930.2 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 112806 Da |
| Antigen Region | 113-141 aa |
| Gene ID | 57639 |
|---|---|
| Other Names | Coiled-coil domain-containing protein 146, CCDC146, KIAA1505 |
| Target/Specificity | This CCDC146 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-141 amino acids from the N-terminal region of human CCDC146. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCDC146 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCDC146 |
|---|---|
| Synonyms | KIAA1505 |
| Function | Essential for sperm flagellum biogenesis and male fertility. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, flagellum axoneme Cytoplasm, cytoskeleton, cilium basal body. Midbody Note=In sperm cells, was seen localized to only one centriole identified as the mother centriole by co-staining with CEP164 (PubMed:25074808). In other experiments, localization to centrioles in sperm cells was not observed (PubMed:38441556). Localizes to the sperm connecting piece and flagellum during spermiogenesis and to the flagellum in spermatozoa from cauda of the epididymis (By similarity) In sperm cell flagellum, may be associated with tubulin doublets (PubMed:38441556). {ECO:0000250|UniProtKB:E9Q9F7, ECO:0000269|PubMed:25074808, ECO:0000269|PubMed:38441556} |
| Tissue Location | Widely expressed.. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The function ofCCDC146 remains unknown.
REFERENCES
Kimura, K., et al. Genome Res. 16(1):55-65(2006)
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