癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RAMP2 Rabbit pAb
RAMP2 Rabbit pAb
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O60895 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 19608 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RAMP2 |
| Epitope Specificity | 81-175/175 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell Membrane; Single-pass type I membrane protein |
| SIMILARITY | Belongs to the RAMP family. |
| SUBUNIT | Heterodimer of CALCRL and RAMP2 |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. |
| Gene ID | 10266 |
|---|---|
| Other Names | Receptor activity-modifying protein 2, Calcitonin-receptor-like receptor activity-modifying protein 2, CRLR activity-modifying protein 2, RAMP2 (HGNC:9844) |
| Target/Specificity | Strongly expressed in lung, breast, immune system and fetal tissues. |
| Dilution | WB=1:500-2000,IHC-P=1:50 - 1:200,IHC-F=1:50 - 1:200,IF=1:50 - 1:200,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | RAMP2 (HGNC:9844) |
|---|---|
| Function | Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene- related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:9620797). Required for the transport of CALCRL to the plasma membrane (PubMed:9620797). Together with CALCRL, form a receptor complex for adrenomedullin/ADM (PubMed:22102369, PubMed:32296767, PubMed:9620797). Together with CALCR, act as a receptor complex for calcitonin/CT/CALC (PubMed:35324283). Together with CALCR, also act as a receptor complex for amylin/IAPP (PubMed:35324283). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Strongly expressed in lung, breast, immune system and fetal tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
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