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Paralemmin 1 Rabbit pAb
Paralemmin 1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O75781 |
| Predicted | Rat, Pig, Dog, Human, Mouse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42076 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Paralemmin 1 |
| Epitope Specificity | 130-230/387 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Basolateral cell membrane; Lipid-anchor (By similarity). Apicolateral cell membrane; Lipid-anchor (By similarity). Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Paralemmin, also called Paralemmin-1 or PALM, is a widely expressed peripheral membrane protein that is involved in cell structure and shape. A hydrophobic protein, Paralemmin is anchored to the cytoplasmic side of the cell membrane via di-palmitoylation and prenylation of its C-terminal cysteine cluster. Functioning at the synapse to regulate neuronal plasticity and plasma membrane dynamics, Paralemmin can bind to the dopamine receptor D3, thereby reducing D3 expression and subsequent adenylate cyclase activity. Overexpression of Paralemmin induces fibroblasts to extend long filopodia and to assume extreme cell shapes, suggesting involvement in the formation and stabilization of the plasma membrane. Two isoforms of Paralemmin exists due to alternative splicing events. |
| Gene ID | 5064 |
|---|---|
| Other Names | Paralemmin-1, Paralemmin, PALM, KIAA0270 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PALM |
|---|---|
| Synonyms | KIAA0270 |
| Function | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon Cell projection, dendrite. Cell projection, dendritic spine. Basolateral cell membrane; Lipid- anchor. Apicolateral cell membrane; Lipid- anchor. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity |
| Tissue Location | Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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