癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GKAP1 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q5VSY0 |
| Other Accession | Q5XIG5, Q9JMB0, Q32LE2, NP_001129425.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42078 Da |
| Antigen Region | 331-359 aa |
| Gene ID | 80318 |
|---|---|
| Other Names | G kinase-anchoring protein 1, cGMP-dependent protein kinase-anchoring protein of 42 kDa, GKAP1, GKAP42 |
| Target/Specificity | This GKAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-359 amino acids from the C-terminal region of human GKAP1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GKAP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GKAP1 |
|---|---|
| Synonyms | GKAP42 |
| Function | Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. |
| Cellular Location | Golgi apparatus {ECO:0000250|UniProtKB:Q9JMB0}. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GKAP1 is a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Lim, J., et al. Cell 125(4):801-814(2006)
Sweetser, D.A., et al. Genes Chromosomes Cancer 44(3):279-291(2005)
Yuasa, K., et al. J. Biol. Chem. 275(7):4897-4905(2000)
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