癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LRRC25 Rabbit pAb
LRRC25 Rabbit pAb
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q8N386 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33179 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LRRC25 |
| Epitope Specificity | 81-180/305 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Single-pass type I membrane protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | LRRC25 is a 305 amino acid protein that contains two LRR repeats. LRRC25 is a single-pass type I membrane protein that is expressed in monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, plasmacytoid dendritic cells (PDC), B-lymphocytes, peripheral blood leukocytes, spleen and bone marrow, with lower levels in lymph nodes, fetal liver, and appendix. LRRC25 may play a role in the activation of cells of innate and acquired immunity. |
| Gene ID | 126364 |
|---|---|
| Other Names | Leucine-rich repeat-containing protein 25, Monocyte and plasmacytoid-activated protein, LRRC25, MAPA |
| Target/Specificity | Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus. |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LRRC25 |
|---|---|
| Synonyms | MAPA |
| Function | Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cytoplasm |
| Tissue Location | Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B- lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
LRRC25 is a 305 amino acid protein that contains two LRR repeats. LRRC25 is a single-pass type I membrane protein that is expressed in monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, plasmacytoid dendritic cells (PDC), B-lymphocytes, peripheral blood leukocytes, spleen and bone marrow, with lower levels in lymph nodes, fetal liver, and appendix. LRRC25 may play a role in the activation of cells of innate and acquired immunity.
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