癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
BDP Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q8IVW6 |
| Reactivity | Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60637 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human BDP/ARID3B |
| Epitope Specificity | 251-350/561 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Contains 1 ARID domain. Contains 1 REKLES domain. |
| SUBUNIT | Heterodimer with ARID3A. Interacts with unphosphorylated RB1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ARID3B represents a member of a unique family of DNA-binding proteins that have roles in cell lineage gene regulation, cell cycle control, embryonic patterning and transcriptional regulation. ARID3B localizes to the nucleus and contains an AT-rich interactive domain (ARID) which has DNA-binding capabilities. Functioning as a transcription factor, ARID3B associates in a heterodimer with the related protein ARID3A and is believed to play an important role in neural crest survival during embryogenesis. In addition, ARID3B may participate in malignant transformation and neuroblastoma growth, suggesting a possible use of ARID3B as a tumor marker for neuroblastoma. |
| Gene ID | 10620 |
|---|---|
| Other Names | AT-rich interactive domain-containing protein 3B, ARID domain-containing protein 3B, Bright and dead ringer protein, Bright-like protein, ARID3B, BDP, DRIL2 |
| Target/Specificity | Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K562 erythrocytic leukemia cells (at protein level). |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | ARID3B |
|---|---|
| Synonyms | BDP, DRIL2 |
| Function | Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:10446990, ECO:0000269|PubMed:17400556} |
| Tissue Location | Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K-562 erythrocytic leukemia cell line (at protein level). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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