癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GCC1 Rabbit pAb
GCC1 Rabbit pAb
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Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96CN9 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Chicken, Dog, Pig, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 87811 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GCC1 |
| Epitope Specificity | 401-500/775 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. |
| SIMILARITY | Contains 1 GRIP domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | GCC1 is a 775 amino acid cytoplasmic and peripheral membrane protein of the Golgi apparatus. Involved in maintenance of Golgi structure, GCC1 is essential for retrograde transport of cargo from the early endosomes to the trans-Golgi network. GCC1 contains one GRIP domain and is encoded by a gene that maps to human chromosome 7q32.1. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. |
| Gene ID | 79571 |
|---|---|
| Other Names | GRIP and coiled-coil domain-containing protein 1, Golgi coiled-coil protein 1, GCC1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | GCC1 |
|---|---|
| Function | Probably involved in maintaining Golgi structure. |
| Cellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GCC1 is a 775 amino acid cytoplasmic and peripheral membrane protein of the Golgi apparatus. Involved in maintenance of Golgi structure, GCC1 is essential for retrograde transport of cargo from the early endosomes to the trans-Golgi network. GCC1 contains one GRIP domain and is encoded by a gene that maps to human chromosome 7q32.1. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
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