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GMPPA Rabbit pAb
GMPPA Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q96IJ6 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46291 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GMPPA |
| Epitope Specificity | 321-420/420 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the transferase hexapeptide repeat family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | GMPPA is a GDP-mannose pyrophosphorylase which catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, in the production of N-linked oligosaccharides. |
| Gene ID | 29926 |
|---|---|
| Other Names | Mannose-1-phosphate guanylyltransferase regulatory subunit alpha, GDP-mannose pyrophosphorylase A, GMPP-alpha, GTP-mannose-1-phosphate guanylyltransferase alpha, GMPPA (HGNC:22923) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | GMPPA (HGNC:22923) |
|---|---|
| Function | Regulatory subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex; reduces the catalytic activity of GMPPB when part of the complex (PubMed:24035193, PubMed:33986552). Mediates allosteric feedback inhibition of GMPPB catalytic activity upon binding GDP-alpha-D-mannose (PubMed:24035193, PubMed:33986552). Together with GMPPB regulates GDP-alpha-D-mannose levels (PubMed:33986552). |
| Cellular Location | Cytoplasm. Note=Myc-tagged GMPPA shows a diffuse cytoplasmic and nuclear pattern in transfected COS-7 cells |
| Tissue Location | Expressed in fibroblasts (at protein level). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GMPPA is a GDP-mannose pyrophosphorylase which catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, in the production of N-linked oligosaccharides.
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¥ 1,500.00
Cat# AP55167
