癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZBED4 Rabbit pAb
ZBED4 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O75132 |
| Reactivity | Human |
| Predicted | Rat, Pig, Mouse, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 130322 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZBED4 |
| Epitope Specificity | 101-200/1171 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasmic and Nuclear |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The zinc finger BED domain-containing protein family (ZBED) is comprised of ZBED1, ZBED2, ZBED3, ZBED4 and ZBED5. They each contain one BED-type zinc finger domains with the exception of ZBED4, which contain 4 BED-type zinc finger domains. ZBED1 is thought to function as a transcription factor that regulates a number of ribosomal protein (RP) encoded genes by binding specifically to 5'-TGTCG[CT]GA[CT]A-3' DNA regions found in RP promotors. ZBED3 is an Axin-binding protein involved in Wnt/beta-catenin signaling modulation. ZBED4 expression has been shown in human and mouse retinas where it is thought to act as a regulatory protein in cone photoreceptors and Müller cells. The functions of ZBED2 and ZBED5 have yet to be elucidated. |
| Gene ID | 9889 |
|---|---|
| Other Names | Zinc finger BED domain-containing protein 4, ZBED4, KIAA0637 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ZBED4 |
|---|---|
| Synonyms | KIAA0637 |
| Function | Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). |
| Cellular Location | Nucleus. Cytoplasm Photoreceptor inner segment |
| Tissue Location | Expressed in testis, heart, lung, and weakly expressed in brain, liver, muscle, placenta and small intestine (PubMed:19369242). Expressed in the retina, found in the cone photoreceptors, Mueller cells, cone pedicles and in the innermost retinal layer (PubMed:19369242). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
