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Tex19A Rabbit pAb
Tex19A Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q99MV2 |
| Reactivity | Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40401 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse Tex19A |
| Epitope Specificity | 1-100/351 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The testis expressed gene 19 (Tex19) is duplicated in mouse and rat to give two genes Tex19.1 and Tex19.2. Tex19.1 expression is limited to pluripotent cells and germ cells, and is downregulated after differentiation. The Tex19.1 (-/-) knockout male mice have impaired spermatogenesis. |
| Gene ID | 73679 |
|---|---|
| Other Names | Testis-expressed protein 19.1, mTex19.1, Testis-expressed protein 19A, Tex19.1 {ECO:0000312|MGI:MGI:1920929}, Tex19, Tex19a |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Tex19.1 {ECO:0000312|MGI:MGI:1920929} |
|---|---|
| Synonyms | Tex19, Tex19a |
| Function | Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and preventing their mobilization (PubMed:18802469, PubMed:21103378, PubMed:23364048, PubMed:23674551, PubMed:28254886). With its paralog, Tex19.2, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:28254886). Also during spermatogenesis, promotes, with UBR2, SPO11-dependent meiotic recombination (PubMed:28708824). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE- 1 retrotransposon mobilization (PubMed:28806172). |
| Cellular Location | Cytoplasm. Note=Was initially reported to localize in the nucleus (PubMed:18096721) However, it was later shown to localize in cytoplasm only (PubMed:18802469). Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:18802469). |
| Tissue Location | Expressed in testis, placenta and ovary. Expressed in pluripotent stem cells. In testis, expression is highest in mitotic spermatogonia, decreases as spermatocytes progress through meiosis, and is present at low levels in round spermatids (at protein level) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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