癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MYCBPAP Rabbit pAb
MYCBPAP Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8TBZ2 |
| Reactivity | Rat, Mouse |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 111926 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MYCBPAP |
| Epitope Specificity | 401-500/947 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Membrane. Colocalizes with MYCBP in the cytoplasm. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | AMAP-1 (AMY-1-binding protein 1), also known as AMAM-1 or MYCBPAP (MYCBP associated protein), is a 947 amino acid protein that is expressed specifically in testis and is involved in spermatogenesis and synaptic processes. AMAP-1 colocalizes with MYCBP (AMY-1) in cytoplasm and also localizes to membrane. The gene encoding AMAP-1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. |
| Gene ID | 84073 |
|---|---|
| Other Names | MYCBP-associated protein, AMAM-1, AMY-1-binding protein 1, AMAP-1, MYCBPAP {ECO:0000312|EMBL:AAH28393.1} |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MYCBPAP {ECO:0000312|EMBL:AAH28393.1} |
|---|---|
| Function | Plays a crucial role in centrosome-nuclear envelope docking during spermiogenesis, a key step for anchoring the centrosome to the nucleus that is essential for proper sperm flagellum biogenesis. Also required for acrosome biogenesis, manchette organization, and spermatid head morphogenesis, contributing to the complete and functional assembly of the sperm flagellum. |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q69CM7}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q5SUV2}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q5SUV2}. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localizes in the sperm flagellum and central apparatus of the flagellar axoneme {ECO:0000250|UniProtKB:Q5SUV2} |
| Tissue Location | [Isoform 2]: Expressed specifically in testis. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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