癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CED6 Rabbit pAb
CED6 Rabbit pAb
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Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9UBP9 |
| Reactivity | Human, Mouse |
| Predicted | Pig, Rabbit, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34490 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CED6 |
| Epitope Specificity | 31-130/304 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Several proteins involved in regulating and executing programmed cell death have been identified in C. elegans. CED-3, a member of the ICE protease/caspase family, and CED-4, a homolog of the mammalian Apaf-1, promote apoptosis. CED-9, a homolog of the mammalian Bcl-2 protein, inhibits cell death. EGL-1 and CED-6 both function as death-promoting proteins, with CED-6 playing a role in the engulfment of apoptotic cells. CED-5 and CED-7 are C. elegans orthologs of the mammalian DOCK180 and ABC transporter proteins, respectively, and also play a role in the engulfment of dying cells. |
| Gene ID | 51454 |
|---|---|
| Other Names | PTB domain-containing engulfment adapter protein 1, Cell death protein 6 homolog, PTB domain adapter protein CED-6, Protein GULP, GULP1, CED6, GULP |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GULP1 |
|---|---|
| Synonyms | CED6, GULP |
| Function | May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. |
| Cellular Location | Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes |
| Tissue Location | Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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